Targeted HAS2 Expression Lessens Airway Responsiveness in Chronic Murine Allergic Airway Disease

Prolonged ozone exposure in an allergic airway disease model: Adaptation of airway responsiveness and airway remodeling

BACKGROUND Short-term exposure to high concentrations of ozone has been shown to increase airway hyper-responsiveness (AHR). Because the changes in AHR and airway inflammation and structure after chronic ozone exposure need to be determined, the goal of this study was to investigate these effects in a murine model of allergic airway disease. METHODS We exposed BALB/c mice to 2 ppm ozone for 4...

Airway responsiveness in CD38-deficient mice in allergic airway disease: studies with bone marrow chimeras.

CD38 is a cell-surface protein involved in calcium signaling and contractility of airway smooth muscle. It has a role in normal airway responsiveness and in airway hyperresponsiveness (AHR) developed following airway exposure to IL-13 and TNF-α but appears not to be critical to airway inflammation in response to the cytokines. CD38 is also involved in T cell-mediated immune response to protein ...

Allergic Fungal Airway Disease.

Fungi are ubiquitous and form their own kingdom. Up to 80 genera of fungi have been linked to type I allergic disease, and yet, commercial reagents to test for sensitization are available for relatively few species. In terms of asthma, it is important to distinguish between species unable to grow at body temperature and those that can (thermotolerant) and thereby have the potential to colonize ...

Airway responsiveness in CD 38 - deficient mice in allergic airway disease : studies 1 with bone marrow chimeras 2 Alonso

Department of Surgical & Radiological Sciences, University of California, Davis, CA; 5 Department of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, 6 MN; Department of Medicine, University of Pennsylvania, Philadelphia, PA; 7 Departments of Immunology and Medicine, Mayo Clinic, Rochester, MN; and Trudeau 8 Institute, Saranac Lake NY, and currently Department of Microbiol...

Lipopolysaccharide-Induced Inflammation Responsiveness and Gender Differences in Murine Airway